Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation
Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The transcriptional response promoted by hypoxia-inducible factors has been associated with metastatic spread of uveal melanoma. We found expression of hypoxia-inducible factor 1α (HIF-1α) protein in well-vascularized tumor regions as well as in four cell lines grown in normoxia, thus this pathway may be important even in well-oxygenated uveal mela...
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Full title
Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation
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TN_cdi_plos_journals_1558100189
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1558100189
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0105372
