Mechanism of the exchange reaction in HRAS from multiscale modeling
Mechanism of the exchange reaction in HRAS from multiscale modeling
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United States: Public Library of Science
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English
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United States: Public Library of Science
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HRAS regulates cell growth promoting signaling processes by cycling between active (GTP-bound) and inactive (GDP-bound) states. Understanding the transition mechanism is central for the design of small molecules to inhibit the formation of RAS-driven tumors. Using a multiscale approach involving coarse-grained (CG) simulations, all-atom classical m...
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Full title
Mechanism of the exchange reaction in HRAS from multiscale modeling
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TN_cdi_plos_journals_1566823334
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1566823334
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0108846
