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Interleukin-1β induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes

Interleukin-1β induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1611598229

Interleukin-1β induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes

About this item

Full title

Interleukin-1β induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes

Publisher

United States: Public Library of Science

Journal title

PloS one, 2014-10, Vol.9 (10), p.e110024-e110024

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The blood-brain barrier (BBB) is composed of capillary endothelial cells, pericytes, and perivascular astrocytes, which regulate central nervous system homeostasis. Sonic hedgehog (SHH) released from astrocytes plays an important role in the maintenance of BBB integrity. BBB disruption and microglial activation are common pathological features of v...

Alternative Titles

Full title

Interleukin-1β induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1611598229

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1611598229

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0110024

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