Interleukin-1β induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes
Interleukin-1β induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The blood-brain barrier (BBB) is composed of capillary endothelial cells, pericytes, and perivascular astrocytes, which regulate central nervous system homeostasis. Sonic hedgehog (SHH) released from astrocytes plays an important role in the maintenance of BBB integrity. BBB disruption and microglial activation are common pathological features of v...
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Full title
Interleukin-1β induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes
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TN_cdi_plos_journals_1611598229
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1611598229
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0110024
