Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate...
Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity
About this item
Full title
Author / Creator
Izzo, Nicholas J , Xu, Jinbin , Zeng, Chenbo , Kirk, Molly J , Mozzoni, Kelsie , Silky, Colleen , Rehak, Courtney , Yurko, Raymond , Look, Gary , Rishton, Gilbert , Safferstein, Hank , Cruchaga, Carlos , Goate, Alison , Cahill, Michael A , Arancio, Ottavio , Mach, Robert H , Craven, Rolf , Head, Elizabeth , LeVine, 3rd, Harry , Spires-Jones, Tara L and Catalano, Susan M
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Amyloid beta (Abeta) 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor proteins is reported to inhibit long-term potentiation, affect membrane trafficking and induce reversible...
Alternative Titles
Full title
Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity
Authors, Artists and Contributors
Author / Creator
Xu, Jinbin
Zeng, Chenbo
Kirk, Molly J
Mozzoni, Kelsie
Silky, Colleen
Rehak, Courtney
Yurko, Raymond
Look, Gary
Rishton, Gilbert
Safferstein, Hank
Cruchaga, Carlos
Goate, Alison
Cahill, Michael A
Arancio, Ottavio
Mach, Robert H
Craven, Rolf
Head, Elizabeth
LeVine, 3rd, Harry
Spires-Jones, Tara L
Catalano, Susan M
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1623314250
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1623314250
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0111899
