Target Modulation by a Kinase Inhibitor Engineered to Induce a Tandem Blockade of the Epidermal Grow...
Target Modulation by a Kinase Inhibitor Engineered to Induce a Tandem Blockade of the Epidermal Growth Factor Receptor (EGFR) and c-Src: The Concept of Type III Combi-Targeting
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Cancer cells are characterized by a complex network of interrelated and compensatory signaling driven by multiple kinases that reduce their sensitivity to targeted therapy. Therefore, strategies directed at inhibiting two or more kinases are required to robustly block the growth of refractory tumour cells. Here we report on a novel strategy to prom...
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Full title
Target Modulation by a Kinase Inhibitor Engineered to Induce a Tandem Blockade of the Epidermal Growth Factor Receptor (EGFR) and c-Src: The Concept of Type III Combi-Targeting
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TN_cdi_plos_journals_1658061987
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1658061987
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0117215
