2-methoxyestradiol induces vasodilation by stimulating NO release via PPARγ/PI3K/Akt pathway
2-methoxyestradiol induces vasodilation by stimulating NO release via PPARγ/PI3K/Akt pathway
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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The endogenous estradiol metabolite 2-methoxyestradiol (2-ME) reduces atherosclerotic lesion formation, while the underlying mechanisms remain obscure. In this work, we investigated the vasodilatory effect of 2-ME and the role of nitric oxide (NO) involved. In vivo studies using noninvasive tail-cuff methods showed that 2-ME decreased blood pressur...
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Full title
2-methoxyestradiol induces vasodilation by stimulating NO release via PPARγ/PI3K/Akt pathway
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TN_cdi_plos_journals_1661102284
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1661102284
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0118902
