Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human...
Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates
About this item
Full title
Author / Creator
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Mutations in glucocerebrosidase (GBA1) cause Gaucher disease and also represent a common risk factor for Parkinson's disease and Dementia with Lewy bodies. Recently, new tool molecules were described which can increase turnover of an artificial substrate 4MUG when incubated with mutant N370S GBA1 from human spleen. Here we show that these compounds...
Alternative Titles
Full title
Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1662631932
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1662631932
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0119141
