Icariin induces synoviolin expression through NFE2L1 to protect neurons from ER stress-induced apopt...
Icariin induces synoviolin expression through NFE2L1 to protect neurons from ER stress-induced apoptosis
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Author / Creator
Li, Fei , Gao, Beixue , Dong, Hongxin , Shi, Jingshan and Fang, Deyu
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
By suppressing neuronal apoptosis, Icariin is a potential therapeutic drug for neuronal degenerative diseases. The molecular mechanisms of Icariin anti-apoptotic functions are still largely unclear. In this report, we found that Icariin induces the expression of Synoviolin, an endoplasmic reticulum (ER)-anchoring E3 ubiquitin ligase that functions...
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Full title
Icariin induces synoviolin expression through NFE2L1 to protect neurons from ER stress-induced apoptosis
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Record Identifier
TN_cdi_plos_journals_1666742129
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1666742129
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0119955
