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Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel ther...

Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel ther...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1667954739

Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel therapies for esophageal/gastro-esophageal junction cancers

About this item

Full title

Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel therapies for esophageal/gastro-esophageal junction cancers

Publisher

United States: Public Library of Science

Journal title

PloS one, 2015-03, Vol.10 (3), p.e0121872

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The high morbidity and mortality of patients with esophageal (E) and gastro-esophageal junction (GEJ) cancers, warrants new pre-clinical models for drug testing. The utility of primary tumor xenografts (PTXGs) as pre-clinical models was assessed. Clinicopathological, immunohistochemical markers (p53, p16, Ki-67, Her-2/neu and EGFR), and global mRNA...

Alternative Titles

Full title

Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel therapies for esophageal/gastro-esophageal junction cancers

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1667954739

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1667954739

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0121872

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