No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiologica...
No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Mutations within the LRRK2 gene have been identified in Parkinson's disease (PD) patients and have been implicated in the dysfunction of several cellular pathways. Here, we explore how pathogenic mutations and the inhibition of LRRK2 kinase activity affect cytoskeleton dynamics in mouse and human cell systems. We generated and characterized a novel...
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No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts
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TN_cdi_plos_journals_1668244546
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1668244546
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0118947
