A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1
A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Crystallization of a maltose-binding protein MCL1 fusion has yielded a robust crystallography platform that generated the first apo MCL1 crystal structure, as well as five ligand-bound structures. The ability to obtain fragment-bound structures advances structure-based drug design efforts that, despite considerable effort, had previously been intra...
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A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1
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TN_cdi_plos_journals_1676150340
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1676150340
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0125010
