Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin
Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin
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Author / Creator
Lukoyanova, Natalya , Kondos, Stephanie C. , Farabella, Irene , Law, Ruby H. P. , Reboul, Cyril F. , Caradoc-Davies, Tom T. , Spicer, Bradley A. , Kleifeld, Oded , Traore, Daouda A. K. , Ekkel, Susan M. , Voskoboinik, Ilia , Trapani, Joseph A. , Hatfaludi, Tamas , Oliver, Katherine , Hotze, Eileen M. , Tweten, Rodney K. , Whisstock, James C. , Topf, Maya , Saibil, Helen R. and Dunstone, Michelle A.
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores via conformational transitions that remain to be structurally and mechanistically characterised. Here we present an 11 Å resolu...
Alternative Titles
Full title
Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin
Authors, Artists and Contributors
Author / Creator
Kondos, Stephanie C.
Farabella, Irene
Law, Ruby H. P.
Reboul, Cyril F.
Caradoc-Davies, Tom T.
Spicer, Bradley A.
Kleifeld, Oded
Traore, Daouda A. K.
Ekkel, Susan M.
Voskoboinik, Ilia
Trapani, Joseph A.
Hatfaludi, Tamas
Oliver, Katherine
Hotze, Eileen M.
Tweten, Rodney K.
Whisstock, James C.
Topf, Maya
Saibil, Helen R.
Dunstone, Michelle A.
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Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1685018789
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1685018789
Other Identifiers
ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.1002049
