Rejuvenation of meiotic cohesion in oocytes during prophase I is required for chiasma maintenance an...
Rejuvenation of meiotic cohesion in oocytes during prophase I is required for chiasma maintenance and accurate chromosome segregation
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Chromosome segregation errors in human oocytes are the leading cause of birth defects, and the risk of aneuploid pregnancy increases dramatically as women age. Accurate segregation demands that sister chromatid cohesion remain intact for decades in human oocytes, and gradual loss of the original cohesive linkages established in fetal oocytes is pro...
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Full title
Rejuvenation of meiotic cohesion in oocytes during prophase I is required for chiasma maintenance and accurate chromosome segregation
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TN_cdi_plos_journals_1685113386
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1685113386
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1004607
