Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation...
Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Homozygous mutations in the glucocerebrosidase (GBA) gene result in Gaucher disease (GD), the most common lysosomal storage disease. Recent genetic studies have revealed that GBA mutations confer a strong risk for sporadic Parkinson's disease (PD). To investigate how GBA mutations cause PD, we generated GBA nonsense mutant (GBA-/-) medaka that are...
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Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein
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TN_cdi_plos_journals_1685143489
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1685143489
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1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1005065
