CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turn...
CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells
About this item
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Author / Creator
Micci, Luca , Alvarez, Xavier , Iriele, Robin I , Ortiz, Alexandra M , Ryan, Emily S , McGary, Colleen S , Deleage, Claire , McAtee, Brigitte B , He, Tianyu , Apetrei, Cristian , Easley, Kirk , Pahwa, Savita , Collman, Ronald G , Derdeyn, Cynthia A , Davenport, Miles P , Estes, Jacob D , Silvestri, Guido , Lackner, Andrew A and Paiardini, Mirko
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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More information
Scope and Contents
Contents
In rhesus macaques (RMs), experimental depletion of CD4+ T-cells prior to SIV infection results in higher viremia and emergence of CD4-independent SIV-envelopes. In this study we used the rhesus recombinant anti-CD4 antibody CD4R1 to deplete RM CD4+ T-cells prior to SIVmac251 infection and investigate the sources of the increased viral burden and t...
Alternative Titles
Full title
CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells
Authors, Artists and Contributors
Author / Creator
Alvarez, Xavier
Iriele, Robin I
Ortiz, Alexandra M
Ryan, Emily S
McGary, Colleen S
Deleage, Claire
McAtee, Brigitte B
He, Tianyu
Apetrei, Cristian
Easley, Kirk
Pahwa, Savita
Collman, Ronald G
Derdeyn, Cynthia A
Davenport, Miles P
Estes, Jacob D
Silvestri, Guido
Lackner, Andrew A
Paiardini, Mirko
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1685245179
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1685245179
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1004467
