Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with Hig...
Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with High In Vitro and In Vivo Potency
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Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Antibody drug conjugates (ADCs) have recently been proven to be highly potent anti-tumor drugs, typically exceeding the efficacy of conventional monoclonal antibodies (mAbs). ADCs are currently produced by chemical conjugation of a small-molecule toxin to the mAb through lysine or cysteine side chains. This leads to heterogeneous mixtures of ADCs i...
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Full title
Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with High In Vitro and In Vivo Potency
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TN_cdi_plos_journals_1692759872
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1692759872
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0131177
