Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly
Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly
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United States: Public Library of Science (PLoS)
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English
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United States: Public Library of Science (PLoS)
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The essential mammalian gene TACC3 is frequently mutated and amplified in cancers and its fusion products exhibit oncogenic activity in glioblastomas. TACC3 functions in mitotic spindle assembly and chromosome segregation. In particular, phosphorylation on S558 by the mitotic kinase, Aurora-A, promotes spindle recruitment of TACC3 and triggers the...
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Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly
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TN_cdi_plos_journals_1705071085
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1705071085
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1005345
