Single Doses up to 800 mg of E-52862 Do Not Prolong the QTc Interval--A Retrospective Validation by...
Single Doses up to 800 mg of E-52862 Do Not Prolong the QTc Interval--A Retrospective Validation by Pharmacokinetic-Pharmacodynamic Modelling of Electrocardiography Data Utilising the Effects of a Meal on QTc to Demonstrate ECG Assay Sensitivity
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United States: Public Library of Science
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English
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United States: Public Library of Science
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E-52862 is a Sigma-1 receptor antagonist (S1RA) currently under investigation as a potential analgesic medicine. We successfully applied a concentration-effect model retrospectively to a four-way crossover Phase I single ascending dose study and utilized the QTc shortening effects of a meal to demonstrate assay sensitivity by establishing the time...
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Single Doses up to 800 mg of E-52862 Do Not Prolong the QTc Interval--A Retrospective Validation by Pharmacokinetic-Pharmacodynamic Modelling of Electrocardiography Data Utilising the Effects of a Meal on QTc to Demonstrate ECG Assay Sensitivity
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TN_cdi_plos_journals_1708567975
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1708567975
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ISSN
1932-6203
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1932-6203
DOI
10.1371/journal.pone.0136369