Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclas...
Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Contents
The cytokine receptor activator of nuclear factor kappa B ligand (RANKL), encoded by the Tnfsf11 gene, is essential for osteoclastogenesis and previous studies have shown that deletion of the Tnfsf11 gene using a Dmp1-Cre transgene reduces osteoclast formation in cancellous bone by more than 70%. However, the Dmp1-Cre transgene used in those studie...
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Full title
Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone
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TN_cdi_plos_journals_1719292472
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1719292472
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0138189
