Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease
Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Dysregulated signaling cascades alter energy metabolism and promote cell proliferation and cyst expansion in polycystic kidney disease (PKD). Here we tested whether metabolic reprogramming towards aerobic glycolysis ("Warburg effect") plays a pathogenic role in male heterozygous Han:SPRD rats (Cy/+), a chronic progressive model of PKD. Using microa...
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Full title
Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease
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TN_cdi_plos_journals_1755799167
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1755799167
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0146654
