An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthm...
An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Different genes are associated with categorical classifications of asthma severity. However, continuous outcomes should be used to catch the heterogeneity of asthma phenotypes and to increase the power in association studies. Accordingly, the aim of this study was to evaluate the association between single nucleotide polymorphisms (SNPs) in candidate gene regions and continuous measures of asthma severity, in adult patients from the general population. In the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (www.geird.org), 326 subjects (aged 20-64) with ever asthma were identified from the general population in Verona (Italy) between 2007 and 2010. A panel of 236 SNPs tagging 51 candidate gene regions (including one or more genes) was analysed. A symptom and treatment score (STS) and pre-bronchodilator FEV1% predicted were used as continuous measures of asthma...
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An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma
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TN_cdi_plos_journals_1774172803
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1774172803
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0151292
