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NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

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NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1805470608

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

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Full title

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

Author / Creator

Ali, Yousuf O , Allen, Hunter M , Yu, Lei , Li-Kroeger, David , Bakhshizadehmahmoudi, Dena , Hatcher, Asante , McCabe, Cristin , Xu, Jishu , Bjorklund, Nicole , Taglialatela, Giulio , Bennett, David A , De Jager, Philip L , Shulman, Joshua M , Bellen, Hugo J and Lu, Hui-Chen

Publisher

United States: Public Library of Science

Journal title

PLoS biology, 2016-06, Vol.14 (6), p.e1002472-e1002472

Language

English

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Articles

Publication information

Publisher

United States: Public Library of Science

Subjects

Subjects and topics

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Scope and Contents

Contents

Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of neurodegeneration. Here, we show that brain nmnat2 mRNA levels correlate positively with global cognitive function and negatively with AD pathology. In AD brains, NMNAT2 mRNA and protein levels are reduced. NMNAT2 shifts its solubility a...

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Full title

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

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Author / Creator

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Record Identifier

TN_cdi_plos_journals_1805470608

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1805470608

Other Identifiers

ISSN

1545-7885,1544-9173

E-ISSN

1545-7885

DOI

10.1371/journal.pbio.1002472

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