3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau...
3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice
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United States: Public Library of Science
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English
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United States: Public Library of Science
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3D volume imaging using iDISCO+ was applied to observe the spatial and temporal progression of tau pathology in deep structures of the brain of a mouse model that recapitulates the earliest stages of Alzheimer's disease (AD). Tau pathology was compared at four timepoints, up to 34 months as it spread through the hippocampal formation and out into t...
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Full title
3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice
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TN_cdi_plos_journals_1807560987
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1807560987
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0159463
