Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysre...
Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta
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Author / Creator
Cabral, Wayne A , Ishikawa, Masaki , Garten, Matthias , Makareeva, Elena N , Sargent, Brandi M , Weis, MaryAnn , Barnes, Aileen M , Webb, Emma A , Shaw, Nicholas J , Ala-Kokko, Leena , Lacbawan, Felicitas L , Högler, Wolfgang , Leikin, Sergey , Blank, Paul S , Zimmerberg, Joshua , Eyre, David R , Yamada, Yoshihiko and Marini, Joan C
Publisher
United States: Public Library of Science
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English
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United States: Public Library of Science
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Contents
Recessive osteogenesis imperfecta (OI) is caused by defects in proteins involved in post-translational interactions with type I collagen. Recently, a novel form of moderately severe OI caused by null mutations in TMEM38B was identified. TMEM38B encodes the ER membrane monovalent cation channel, TRIC-B, proposed to counterbalance IP3R-mediated Ca2+...
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Full title
Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta
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TN_cdi_plos_journals_1811744615
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1811744615
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1006156
