A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitocho...
A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration
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United States: Public Library of Science
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English
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United States: Public Library of Science
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We previously reported that hypoxia-inducible factor (HIF)-1 inhibitor LW6, an aryloxyacetylamino benzoic acid derivative, inhibits malate dehydrogenase 2 (MDH2) activity during the mitochondrial tricarboxylic acid (TCA) cycle. In this study, we present a novel MDH2 inhibitor compound 7 containing benzohydrazide moiety, which was identified through...
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Full title
A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration
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TN_cdi_plos_journals_1818049428
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1818049428
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0162568
