The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy
The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The structure of the infectious prion protein (PrPSc), which is responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, has escaped all attempts at elucidation due to its insolubility and propensity to aggregate. PrPSc replicates by converting the non-infectious, cellular prion protein (PrPC) into the misfolded, in...
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Full title
The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy
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TN_cdi_plos_journals_1829442559
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1829442559
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1005835
