Tbx5 Buffers Inherent Left/Right Asymmetry Ensuring Symmetric Forelimb Formation
Tbx5 Buffers Inherent Left/Right Asymmetry Ensuring Symmetric Forelimb Formation
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The forelimbs and hindlimbs of vertebrates are bilaterally symmetric. The mechanisms that ensure symmetric limb formation are unknown but they can be disrupted in disease. In Holt-Oram Syndrome (HOS), caused by mutations in TBX5, affected individuals have left-biased upper/forelimb defects. We demonstrate a role for the transcription factor Tbx5 in...
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Full title
Tbx5 Buffers Inherent Left/Right Asymmetry Ensuring Symmetric Forelimb Formation
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TN_cdi_plos_journals_1858865334
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1858865334
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1006521
