Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity...
Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes
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Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Deficiency of glucocerebrosidase (GBA) causes Gaucher disease (GD). In the common non-neuronopathic GD type I variant, glucosylceramide accumulates primarily in the lysosomes of visceral macrophages. Supplementing storage cells with lacking enzyme is accomplished via chronic intravenous administration of recombinant GBA containing mannose-terminate...
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Full title
Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes
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TN_cdi_plos_journals_1869029962
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1869029962
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0170268
