EV71 3D Protein Binds with NLRP3 and Enhances the Assembly of Inflammasome Complex
EV71 3D Protein Binds with NLRP3 and Enhances the Assembly of Inflammasome Complex
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Author / Creator
Wang, Wenbiao , Xiao, Feng , Wan, Pin , Pan, Pan , Zhang, Yecheng , Liu, Fang , Wu, Kailang , Liu, Yingle and Wu, Jianguo
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Activation of NLRP3 inflammasome is important for effective host defense against invading pathogen. Together with apoptosis-associated speck-like protein containing CARD domain (ASC), NLRP3 induces the cleavage of caspase-1 to facilitate the maturation of interleukin-1beta (IL-1β), an important pro-inflammatory cytokine. IL-1β subsequently plays cr...
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Full title
EV71 3D Protein Binds with NLRP3 and Enhances the Assembly of Inflammasome Complex
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Author / Creator
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Record Identifier
TN_cdi_plos_journals_1869527706
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1869527706
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1006123
