SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing
SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing
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Cui, Ye , Yu, Huansha , Zheng, Xin , Peng, Rui , Wang, Qiang , Zhou, Yi , Wang, Rui , Wang, Jiehua , Qu, Bo , Shen, Nan , Guo, Qiang , Liu, Xing and Wang, Chen
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Cyclic GMP-AMP (cGAMP) synthase (cGAS, a.k.a. MB21D1), a cytosolic DNA sensor, catalyzes formation of the second messenger 2'3'-cGAMP that activates the stimulator of interferon genes (STING) signaling. How the cGAS activity is modulated remains largely unknown. Here, we demonstrate that sentrin/SUMO-specific protease 7 (SENP7) interacted with and...
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Full title
SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing
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TN_cdi_plos_journals_1869528435
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1869528435
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1006156
