A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation...
A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer
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United States: Public Library of Science
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English
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United States: Public Library of Science
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HMG-box proteins, including Sox/SRY (Sox) and TCF/LEF1 (TCF) family members, bind DNA via their HMG-box. This binding, however, is relatively weak and both Sox and TCF factors employ distinct mechanisms for enhancing their affinity and specificity for DNA. Here we report that Capicua (CIC), an HMG-box transcriptional repressor involved in Ras/MAPK...
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Full title
A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer
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TN_cdi_plos_journals_1888656419
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1888656419
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1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1006622
