Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease
About this item
Full title
Author / Creator
Kerr, Fiona , Sofola-Adesakin, Oyinkan , Ivanov, Dobril K , Gatliff, Jemma , Gomez Perez-Nievas, Beatriz , Bertrand, Hélène C , Martinez, Pedro , Callard, Rebecca , Snoeren, Inge , Cochemé, Helena M , Adcott, Jennifer , Khericha, Mobina , Castillo-Quan, Jorge Iván , Wells, Geoffrey , Noble, Wendy , Thornton, Janet and Partridge, Linda
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer's disease (AD). Current Nrf2 activators, however, may exert toxicity and pathway over-activation can induce detrimental effects. An understanding of the mechanisms mediating Nrf2 inhib...
Alternative Titles
Full title
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease
Authors, Artists and Contributors
Author / Creator
Sofola-Adesakin, Oyinkan
Ivanov, Dobril K
Gatliff, Jemma
Gomez Perez-Nievas, Beatriz
Bertrand, Hélène C
Martinez, Pedro
Callard, Rebecca
Snoeren, Inge
Cochemé, Helena M
Adcott, Jennifer
Khericha, Mobina
Castillo-Quan, Jorge Iván
Wells, Geoffrey
Noble, Wendy
Thornton, Janet
Partridge, Linda
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1888656420
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1888656420
Other Identifiers
ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1006593
