Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygen...
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
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Author / Creator
Desikan, Rahul S , Fan, Chun Chieh , Wang, Yunpeng , Schork, Andrew J , Cabral, Howard J , Cupples, L Adrienne , Thompson, Wesley K , Besser, Lilah , Kukull, Walter A , Holland, Dominic , Chen, Chi-Hua , Brewer, James B , Karow, David S , Kauppi, Karolina , Witoelar, Aree , Karch, Celeste M , Bonham, Luke W , Yokoyama, Jennifer S , Rosen, Howard J , Miller, Bruce L , Dillon, William P , Wilson, David M , Hess, Christopher P , Pericak-Vance, Margaret , Haines, Jonathan L , Farrer, Lindsay A , Mayeux, Richard , Hardy, John , Goate, Alison M , Hyman, Bradley T , Schellenberg, Gerard D , McEvoy, Linda K , Andreassen, Ole A and Dale, Anders M
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk prediction.
Using genotype data from 17,008 AD cases and 37,154 controls from th...
Alternative Titles
Full title
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
Authors, Artists and Contributors
Author / Creator
Fan, Chun Chieh
Wang, Yunpeng
Schork, Andrew J
Cabral, Howard J
Cupples, L Adrienne
Thompson, Wesley K
Besser, Lilah
Kukull, Walter A
Holland, Dominic
Chen, Chi-Hua
Brewer, James B
Karow, David S
Kauppi, Karolina
Witoelar, Aree
Karch, Celeste M
Bonham, Luke W
Yokoyama, Jennifer S
Rosen, Howard J
Miller, Bruce L
Dillon, William P
Wilson, David M
Hess, Christopher P
Pericak-Vance, Margaret
Haines, Jonathan L
Farrer, Lindsay A
Mayeux, Richard
Hardy, John
Goate, Alison M
Hyman, Bradley T
Schellenberg, Gerard D
McEvoy, Linda K
Andreassen, Ole A
Dale, Anders M
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1888656422
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1888656422
Other Identifiers
ISSN
1549-1676,1549-1277
E-ISSN
1549-1676
DOI
10.1371/journal.pmed.1002258
