Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS
Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders that exist on a symptomological spectrum and share both genetic underpinnings and pathophysiological hallmarks. Functional abnormality of TAR DNA-binding protein 43 (TDP-43), an aggregation-prone RNA and DNA binding protein...
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Full title
Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS
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TN_cdi_plos_journals_1888656450
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1888656450
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1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1006635
