Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deleti...
Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The cytoplasmic peptide:N-glycanase (Ngly1 in mammals) is a de-N-glycosylating enzyme that is highly conserved among eukaryotes. It was recently reported that subjects harboring mutations in the NGLY1 gene exhibited severe systemic symptoms (NGLY1-deficiency). While the enzyme obviously has a critical role in mammals, its precise function remains u...
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Full title
Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene
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TN_cdi_plos_journals_1899331285
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1899331285
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1006696
