A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-[alpha] levels in...
A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-[alpha] levels in human melioidosis
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Author / Creator
Limmathurotsakul, Direk , Burtnick, Mary N , Chantratita, Narisara , Day, Nicholas P. J , Brett, Paul J , Dunachie, Susanna J , Jenjaroen, Kemajittra , Chaichana, Panjaporn , Koosakulnirand, Sirikamon , Chumseng, Suchintana , West, T. Eoin , Teparrukkul, Prapit , Brod, Florian and Sumonwiriya, Manutsanun
Publisher
San Francisco: Public Library of Science
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Language
English
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Publisher
San Francisco: Public Library of Science
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Contents
Background Melioidosis, caused by the flagellated bacterium Burkholderia pseudomallei, is a life-threatening and increasingly recognized emerging disease. Toll-like receptor (TLR) 5 is a germline-encoded pattern recognition receptor to bacterial flagellin. We evaluated the association of a nonsense TLR5 genetic variant that truncates the receptor w...
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Full title
A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-[alpha] levels in human melioidosis
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TN_cdi_plos_journals_1910461994
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1910461994
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ISSN
1935-2727
E-ISSN
1935-2735
DOI
10.1371/journal.pntd.0005587
