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Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade

Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1936206894

Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade

About this item

Full title

Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade

Publisher

United States: Public Library of Science

Journal title

PloS one, 2017-09, Vol.12 (9), p.e0184068

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Previous data indicate that Tankyrase inhibitors exert anti-growth functions in many cancer cell lines due to their ability to inactivate the YAP protooncogene. In the present manuscript, we investigated the effect of Tankyrase inhibitors on the growth of hepatocellular carcinoma (HCC) cell lines and the molecular mechanisms involved. For this purp...

Alternative Titles

Full title

Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1936206894

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1936206894

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0184068

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