Separation of anti-proliferation and anti-apoptotic functions of retinoblastoma protein through targ...
Separation of anti-proliferation and anti-apoptotic functions of retinoblastoma protein through targeted mutations of its A/B domain
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The human retinoblastoma susceptibility gene encodes a nuclear phosphoprotein RB, which is a negative regulator of cell proliferation. The growth suppression function of RB requires an evolutionarily conserved A/B domain that contains two distinct peptide-binding pockets. At the A/B interface is a binding site for the C-terminal trans-activation do...
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Full title
Separation of anti-proliferation and anti-apoptotic functions of retinoblastoma protein through targeted mutations of its A/B domain
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TN_cdi_plos_journals_1949666699
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1949666699
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0000082
