Immunogenicity of glycans on biotherapeutic drugs produced in plant expression systems—The taligluce...
Immunogenicity of glycans on biotherapeutic drugs produced in plant expression systems—The taliglucerase alfa story
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Plants are a promising alternative for the production of biotherapeutics. Manufacturing in-planta adds plant specific glycans. To understand immunogenic potential of these glycans, we developed a validated method to detect plant specific glycan antibodies in human serum. Using this assay, low prevalence of pre-existing anti-plant glycan antibodies...
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Full title
Immunogenicity of glycans on biotherapeutic drugs produced in plant expression systems—The taliglucerase alfa story
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TN_cdi_plos_journals_1958248597
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1958248597
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0186211
