Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability a...
Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Immune evasion is a well-recognized hallmark of cancer and recent studies with immunotherapy agents have suggested that tumors with increased numbers of neoantigens elicit greater immune responses. We hypothesized that the immune system presents a common selective pressure on high mutation burden tumors and therefore immune evasion mutations would...
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Full title
Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion
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TN_cdi_plos_journals_1962274844
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1962274844
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0176181
