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Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in r...

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in r...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2014512268

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques

About this item

Full title

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques

Publisher

United States: Public Library of Science

Journal title

PLoS pathogens, 2018-02, Vol.14 (2), p.e1006913-e1006913

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The native-like, soluble SOSIP.664 trimer based on the BG505 clade A env gene of HIV-1 is immunogenic in various animal species, of which the most studied are rabbits and rhesus macaques. The trimer induces autologous neutralizing antibodies (NAbs) consistently but at a wide range of titers and with incompletely determined specificities. A precise...

Alternative Titles

Full title

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2014512268

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2014512268

Other Identifiers

ISSN

1553-7374,1553-7366

E-ISSN

1553-7374

DOI

10.1371/journal.ppat.1006913

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