Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in ly...
Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes
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Author / Creator
Watson, Dionysios C , Moysi, Eirini , Valentin, Antonio , Bergamaschi, Cristina , Devasundaram, Santhi , Fortis, Sotirios P , Bear, Jenifer , Chertova, Elena , Bess, Jr, Julian , Sowder, Ray , Venzon, David J , Deleage, Claire , Estes, Jacob D , Lifson, Jeffrey D , Petrovas, Constantinos , Felber, Barbara K and Pavlakis, George N
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
B cell follicles in secondary lymphoid tissues represent an immune privileged sanctuary for AIDS viruses, in part because cytotoxic CD8+ T cells are mostly excluded from entering the follicles that harbor infected T follicular helper (TFH) cells. We studied the effects of native heterodimeric IL-15 (hetIL-15) treatment on uninfected rhesus macaques...
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Full title
Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes
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TN_cdi_plos_journals_2014518564
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2014518564
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1006902
