Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling
Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
The HMG-CoA reductase inhibitors, statins, have been used as lipid lowering drugs for decades and several epidemiological studies suggest statin usage correlates with a decreased incidence of cancer specific mortality in patients. However, the mechanism of this mortality benefit remains unclear. Here, we demonstrate that statin drug lipophilicity a...
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Full title
Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling
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TN_cdi_plos_journals_2039224467
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2039224467
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0197422
