Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice
Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
The enzyme glucocerebrosidase (GBA) hydrolyses glucosylceramide (GlcCer) in lysosomes. Markedly reduced GBA activity is associated with severe manifestations of Gaucher disease including neurological involvement. Mutations in the GBA gene have recently also been identified as major genetic risk factor for Parkinsonism. Disturbed metabolism of GlcCe...
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Full title
Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice
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TN_cdi_plos_journals_2043684417
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2043684417
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0135889
