Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to p...
Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Birt-Hogg-Dube' Syndrome (BHDS) is a rare genetic disorder in humans characterized by skin hamartomas, lung cysts, pneumothorax, and increased risk of renal tumors. BHDS is caused by mutations in the BHD gene, which encodes for Folliculin, a cytoplasmic adapter protein that binds to Folliculin interacting proteins-1 and -2 (Fnip1, Fnip2) as well as...
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Full title
Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation
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TN_cdi_plos_journals_2054901820
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2054901820
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0197973
