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Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access

Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2055917121

Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access

About this item

Full title

Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access

Publisher

United States: Public Library of Science

Journal title

PloS one, 2018-06, Vol.13 (6), p.e0198990

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

D-amino acid oxidase (DAAO) degrades D-amino acids to produce α-ketoacids, hydrogen peroxide and ammonia. DAAO has often been investigated and engineered for industrial and clinical applications. We combined information from literature with a detailed analysis of the structure to engineer mammalian DAAOs. The structural analysis was complemented wi...

Alternative Titles

Full title

Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2055917121

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2055917121

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0198990

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