BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains
BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains
About this item
Full title
Author / Creator
Causevic, Mirsada , Dominko, Kristina , Malnar, Martina , Vidatic, Lea , Cermak, Stjepko , Pigoni, Martina , Kuhn, Peer-Hendrik , Colombo, Alessio , Havas, Daniel , Flunkert, Stefanie , McDonald, Jessica , Gunnersen, Jenny M , Hutter-Paier, Birgit , Tahirovic, Sabina , Windisch, Manfred , Krainc, Dimitri , Lichtenthaler, Stefan F and Hecimovic, Silva
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
It is intriguing that a rare, inherited lysosomal storage disorder Niemann-Pick type C (NPC) shares similarities with Alzheimer's disease (AD). We have previously reported an enhanced processing of β-amyloid precursor protein (APP) by β-secretase (BACE1), a key enzyme in the pathogenesis of AD, in NPC1-null cells. In this work, we characterized reg...
Alternative Titles
Full title
BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains
Authors, Artists and Contributors
Author / Creator
Dominko, Kristina
Malnar, Martina
Vidatic, Lea
Cermak, Stjepko
Pigoni, Martina
Kuhn, Peer-Hendrik
Colombo, Alessio
Havas, Daniel
Flunkert, Stefanie
McDonald, Jessica
Gunnersen, Jenny M
Hutter-Paier, Birgit
Tahirovic, Sabina
Windisch, Manfred
Krainc, Dimitri
Lichtenthaler, Stefan F
Hecimovic, Silva
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2065388365
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2065388365
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0200344
