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A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation usi...

A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation usi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2156484119

A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1

About this item

Full title

A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1

Publisher

United States: Public Library of Science

Journal title

PloS one, 2018-12, Vol.13 (12), p.e0208979-e0208979

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

LIM kinases are located at a strategic crossroad, downstream of several signaling pathways and upstream of effectors such as microtubules and the actin cytoskeleton. Cofilin is the only LIM kinases substrate that is well described to date, and its phosphorylation on serine 3 by LIM kinases controls cofilin actin-severing activity. Consequently, LIM...

Alternative Titles

Full title

A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2156484119

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2156484119

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0208979

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