Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer'...
Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes
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Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Human mini-brains (MB) are cerebral organoids that recapitulate in part the complexity of the human brain in a unique three-dimensional in vitro model, yielding discrete brain regions reminiscent of the cerebral cortex. Specific proteins linked to neurodegenerative disorders are physiologically expressed in MBs, such as APP-derived amyloids (Aβ), w...
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Full title
Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes
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TN_cdi_plos_journals_2157875026
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2157875026
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0209150
