T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in...
T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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T-type calcium channels in the brain mediate the pathophysiology of epilepsy, pain, and sleep. Recently, we developed a novel therapeutic candidate, SAK3 (ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopentane-1,3'-imidazo[1,2-a] pyridine]-2-ene-3-carboxylate), for Alzheimer's disease (AD). The cognitive improvement by SAK3 is closely...
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Full title
T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice
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TN_cdi_plos_journals_2159330984
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2159330984
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0206986
